You made it through the hardest part
Now don't get taken down by the side effects.
Secondary immunodeficiency can happen after common therapies and chronic illnesses—leaving you vulnerable to infections, gut issues, fatigue, and slower recovery. NostraBiome helps you support immune resilience by modulating the microbiome—before therapy and when immune suppression appears.
A quiet pandemic after modern medicine
Many people survive the main disease—cancer, autoimmune flares, transplant journeys, severe infections—yet later struggle with a new problem: secondary immunodeficiency caused by the illness itself or by life-saving therapies.
We call it a "pandemic" in the sense that it's widespread, under-recognized, and life-disrupting—not because it's contagious.
When your immune system is drained, even "minor" infections and gut symptoms can become the hardest part.
What is secondary immunodeficiency?
Secondary immunodeficiency means your immune defenses become weaker because of something else—like treatment, another disease, stress on the body, or malnutrition. It can be temporary or longer-lasting, mild or severe.
Common causes
Chemotherapy / radiotherapy
Steroids and some immunosuppressants
Chronic illnesses, severe infections, malnutrition
Symptoms patients recognize
Frequent infections or slow recovery
Gut issues (diarrhea/constipation, pain, bloating)
Mouth/throat problems, skin flares
Exhaustion that "doesn't match" activity
Clinician note
"Secondary immunodeficiency" includes therapy-related immune suppression, barrier dysfunction, and susceptibility to opportunistic infection—often overlapping with inflammation and dysbiosis.
Why the gut matters when immunity is stressed
For patients:
Your gut isn't just digestion—it's a major interface between your body and the outside world. When the microbiome is disrupted, people can experience more inflammation, worse GI symptoms, and a harder time bouncing back.
For clinicians:
Microbiome–immune crosstalk influences mucosal barrier function, inflammatory tone, and immune signaling. Therapy-related dysbiosis is common and may amplify symptoms.
Before therapy: reduce the likelihood and impact of secondary immunodeficiency
Prepare the terrain before the storm.
What we aim to support
Help maintain a more stable microbiome during stressful treatment periods
Support gut barrier integrity and digestive tolerance
Support resilience (sleep, nutrition, inflammation drivers) that can affect symptom severity
Important
Not a substitute for prophylaxis, antimicrobials, vaccines, or oncology/immune protocols. A supportive layer aimed at gut–immune stabilization.
When immune suppression shows up: modulate for lower symptom burden
Early support can reduce how hard this phase feels.
What we can support
Reduce symptom intensity by supporting microbiome balance and gut comfort
Support nutrition tolerance when appetite, nausea, diarrhea, or constipation appear
Support recovery routines during vulnerable windows (sleep, hydration, gentle fueling)
Act early
If you notice frequent infections, persistent gut symptoms, or prolonged fatigue during/after therapy, bring it up immediately with your care team.
What "microbiome modulation technology" means here
NostraBiome is a structured, personalized approach to microbiome support—combining symptom patterns, risk factors, and tolerance to guide what to add, avoid, and adjust throughout therapy phases.
Any supplements or dietary changes should be reviewed with your clinician—especially during immune suppression.
Safety first—especially when immunity is low
Extra caution required
Immunosuppressed patients need extra caution with interventions, supplements, and "one-size-fits-all" probiotics.
Clinician coordination
We encourage coordination with your clinician to ensure all interventions are appropriate for your situation.
Red flags requiring urgent care
If you experience any of these, seek immediate medical evaluation:
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Fever or chills
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Severe or bloody diarrhea
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Signs of dehydration
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Unusual or worsening infections
You're not alone in this phase
Sarah M.: "After chemo, my gut was a mess and I kept getting sick. The microbiome support plan helped me understand what was happening and gave me practical steps that actually worked with my treatment schedule."
Dr. Jennifer L., Oncologist: "Supporting the microbiome during immunosuppressive therapy is an emerging area with real potential. Having a structured approach that patients can discuss with their care team adds value to symptom management."
Frequently asked questions
Clinician Overview
Intended use
NostraBiome provides a supportive care layer for therapy-associated dysbiosis and related symptoms. It is designed to complement, not replace, standard medical protocols.
Communication & collaboration
Patients receive shareable summaries suitable for chart documentation. We encourage direct communication with care teams and offer optional clinician collaboration for complex cases.
Safety guardrails
Special considerations for immunocompromised patients:
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Avoidance of contraindicated ingredients during severe immunosuppression
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Strain-specific probiotic selection based on safety data
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Alignment with oncology/immunology protocols
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Red flag symptom recognition and urgent care referral
Outcomes tracked
We monitor symptom burden, treatment tolerance, and nutrition/hydration stability. We do not claim to restore immune function—our focus is on quality of life and symptom management during vulnerable phases.
Choose your path
Get a personalized report to optimize your microbiome based on nutritional changes, lifestyle adjustments, supplements, and living biotics with precise dosage tailored to your situation.