We look into the elements no one was looking at before—how oral microbiome imbalances fuel inflammation at a molecular level. Pathogens like Porphyromonas gingivalis and Treponema denticola trigger immune responses that drive tissue damage. Restoring microbial balance through probiotics and targeted antimicrobials offers a new path to reducing inflammation and protecting oral health.

Your body sends multiple signals—sometimes without an obvious reason. Our technology connects these signals to your microbiome and disease, decoding their meaning to uncover hidden patterns of inflammation, immune response, and health imbalances.

We decode immune pathways by connecting microbial signatures to immune activity—tracing how bacteria, metabolites, and dysbiosis trigger inflammation or tolerance. By mapping these interactions, we uncover hidden drivers of immune dysfunction and pave the way for targeted interventions to restore balance

The combination and group of strains or species responsible for various damages, symptoms, and clinical manifestations observed in the assessed patient. While these microorganisms are not necessarily pathogenic, their expression, abundance, and virulence in the specific context of the patient's microbiome actively contribute to altered immune responses. Typically, the Disease-Manifesting Microbiome Signature (DMIS) comprises a wide array of strains shared among individuals exhibiting similar symptoms, consistent with Koch's postulates. However, certain strains that are pathogenic in some cases may remain completely harmless in other individuals, depending on the specific microbiome environment and host factors.

By understanding the exact pathways and connections between your microbiome, immune activity, and disease signals, we can predict how standard care therapies will work for you. Our technology personalizes recommendations to enhance treatment efficacy, ensuring targeted interventions that optimize your health.

We identify the unique inflammation sources from your gut and how they interact with your body and other organs—elements no one was looking at before. Gut dysbiosis fuels systemic inflammation. These unique imbalances and hidden signals can trigger conditions from IBD to metabolic disorders. Restoring microbial harmony through precision probiotics, metabolite-based therapies, and dietary interventions offers a targeted approach to gut and overall health.

This is an internal predictive score generated by our technology that estimates the level of immune load and unnecessary stress caused by improper strain activity and their expression within the measured microbiome. As the microbiome represents the largest living ecosystem in the human body, its true chemical impact has largely been overlooked until now. This score is crucial for understanding the extent to which a particular microbiome may be detrimental to its host's immune system

Your microbiome influences sleep through neurotransmitter production, inflammation control, and gut-brain communication. By analyzing microbial activity, circadian rhythm interactions, and metabolic byproducts, we identify hidden factors affecting sleep quality, duration, and recovery.

Your microbiome directly influences brain function and mood through the gut-brain axis. By analyzing microbial metabolites, neurotransmitter production, and inflammation pathways, we uncover hidden factors affecting cognition, stress, and mental well-being. Our advanced technology predicts how your microbiome impacts brain health and provides personalized strategies to enhance focus, emotional balance, and overall mental resilience.

Your gut microbiome constantly communicates with your immune system through chemical metabolites, influencing inflammation and disease progression. By mapping these interactions, we identify hidden microbial imbalances driving digestive disorders, from IBD to metabolic dysfunctions. Our advanced analysis predicts how your microbiome impacts immune responses and tailors strategies to enhance treatment effectiveness, restoring gut health at its core

Your oral microbiome plays a key role in inflammation, immunity, and overall health. By analyzing bacterial composition, metabolite activity, and immune responses, we identify hidden factors contributing to gum disease, cavities, and systemic inflammation. Our advanced technology predicts how your microbiome impacts oral health and provides personalized strategies to restore balance, prevent disease, and improve overall well-being.

Your immune system reacts to microbial signals in ways that can trigger or regulate inflammation. By decoding these immune pathways, we identify hidden microbial influences on immune activity, autoimmunity, and chronic inflammation. Our advanced analysis predicts how your immune system will respond to therapies and provides personalized strategies to enhance immune balance and treatment outcomes.

Your microbiome plays a critical role in metabolism, fat storage, and energy balance. By analyzing microbial composition, nutrient processing, and hormone interactions, we identify hidden factors affecting weight gain, insulin resistance, and metabolic efficiency

Your microbiome plays a crucial role in energy production, metabolism, and recovery. By analyzing microbial composition, metabolite production, and nutrient absorption pathways, we uncover hidden factors affecting fatigue, endurance, and overall performance. Our advanced technology predicts how your microbiome influences energy levels and provides personalized strategies to optimize metabolism, boost vitality, and enhance physical and mental performance.

What you eat directly interacts with your microbiome, shaping digestion, nutrient absorption, and metabolism. By analyzing how your gut microbes process different foods, produce essential metabolites, and influence inflammation, we uncover hidden factors affecting your nutritional health.

To get started, you are not required to subscribe to one of our plans, which include a test, recommendations, and products bundled together. In fact, we offer multiple approaches tailored to fit different conditions. For IBD (Inflammatory Bowel Disease)—where we have the most experience—we provide a fully personalized treatment plan. This includes recurrent test kits, in-depth profiling, diagnosis, and a treatment recommendation reviewed and approved by our internal medical team. For other immune diseases, we offer specific tests that can help uncover hidden underlying causes, providing valuable insights for both you and your doctor. For a fully personalized experience, we will soon launch a subscription service that, in addition to tests and recommendations, will offer continuous communication and direct interaction with our medical team.

No, the AI functions as a support tool, helping our internal medical team uncover hidden correlations within over 40 million data points that may contribute to your condition. While the system generates recommendations, only our doctors have the authority to make medical decisions and approve the final treatment plan for you.

There is no single answer, as everything depends entirely on the underlying cause of the disease. Every patient is different, and therefore, each treatment and set of recommendations is uniquely tailored. Regardless of your progress, we recommend staying in close contact with us for at least 12 months—even if your symptoms disappear—to ensure they do not relapse.

Since our recommendations may include over-the-counter medications, along with nutritional, lifestyle, and dietary supplements, our team is composed of highly skilled, certified gastroenterologists, infectiologists, immunologists, and nutritionists. They work together to carefully assess your case and ensure that all AI-generated recommendations are both safe and medically validated.

Every NostraBiome journey begins with a test. Our most advanced test is the NostraBiome Metagenomic Microbiome Intelligence, which provides everything needed to analyze every single microbe and bacterium living in your body. With our Full Metagenomic Test, NostraBiome examines microbiome activity across your body using our proprietary NostraAi technology. Combined with metagenomic DNA sequencing, this approach delivers the highest-resolution insights into your body's status quo, revealing critical links between the microbiome and other organs. This unique capability allows us to provide precise and highly accurate recommendations for autoimmune and chronic conditions. In addition to the test, we ask you to complete a comprehensive health profiling questionnaire. Depending on the complexity of your condition, we may also request previously tested blood marker values. All of this data is fed into our NostraAi engine, which analyzes gene expression across your body. Our AI then sorts through millions of data points, identifying the most effective drugs, foods, nutrients, and ingredients to help reduce immune pathway activations that trigger your symptoms.

NostraBiome is the only company that combines DNA sequencing, advanced user profiling, and blood test data to understand not just which microbes are present in your microbiome, but also what they are actively doing in your body compared to someone else’s. Microbes can behave differently—either beneficially or harmfully—depending on an individual’s environment. What sets NostraBiome apart is our ability to analyze how your microbiome interacts with you as its human host. You are in a symbiotic relationship with your microbiome, and when it functions suboptimally, your health can suffer. We also take a systems biology approach, meaning we assess the body as a whole—examining cellular, molecular, organ, and tissue systems holistically—to identify the root causes of dysfunction that may lead to illness or symptoms you experience daily. Rather than focusing on symptoms alone, we target the underlying causes. While some tests focus only on DNA, we understand that measuring superficial health markers alone won’t provide long-term support or enhance your body’s resilience against the internal and environmental stressors you face every day.

Depending on the complexity of your condition and the solution you choose, a fully personalized plan may take up to six weeks to be curated for you. The most time-consuming component is typically metagenomic sequencing, which, due to the complexity and vast amount of data generated, usually takes around four weeks to complete.