Are you living with a rare disease?
Even with cutting-edge therapies, many people still struggle with fatigue, gut symptoms, inflammation, infections, flares, or medication side effects. NostraBiome adds a complementary, personalized microbiome-based layer designed to help your body tolerate therapy better and function more steadily.
Why you can be "treated" but still feel unwell
Rare diseases are often approached with novel, highly specific medical solutions—gene therapies, enzyme replacement, targeted biologics, pathway inhibitors, precision drugs. These can be life-changing, yet outcomes vary widely.
Sometimes the "main problem" is being addressed—yet additional immune and inflammatory stressors keep the body from stabilizing.
NostraBiome is a complementary layer—built for rare disease complexity
NostraBiome does not claim to treat or cure rare diseases. Instead, we help personalize and optimize the body conditions that influence how you feel and how well you tolerate therapy.
Core idea
We start with the gut microbiome and use multi-omic interpretation (microbiome patterns + symptoms + relevant context such as medications, diet, labs when available) to guide a careful modulation plan.
Why the gut is central:
The gut ecosystem produces and modifies a wide range of bioactive compounds (metabolites) that interact with immune signaling, inflammation tone, and barrier integrity.
When that system is disturbed, people may experience more symptoms and more medication intolerance.
Your gut is one of the body's biggest chemical "factories"
Your gut microbiome helps generate and transform chemicals that can influence:
Supporting this internal chemistry can help create a healthier baseline—so therapy has a better environment to work in.
Before therapy: optimize your baseline and reduce avoidable disruption
Goal: Support a steadier internal environment so your body is better prepared for change.
What we target:
Improve gut stability and comfort
Support barrier resilience and nutritional tolerance
Reduce common disruptors where safe (e.g., mismatch of diet/supplements to symptoms, unnecessary triggers)
Establish a monitoring baseline so changes are caught early
During therapy: reduce symptom burden and improve day-to-day tolerance
Goal: Help you feel more stable while you stay on the treatment that matters.
Common therapy-phase struggles we support:
GI side effects (nausea, diarrhea/constipation, bloating, pain)
Appetite and food tolerance changes
Fatigue patterns that worsen with gut instability
Frequent "off days" after doses or cycles
What NostraBiome does here:
How our proprietary interpretation works
For clinicians: We can provide a concise summary suitable for clinical discussion.
Safety matters more in rare disease
Extra caution required
If you are immunocompromised or medically fragile, "standard wellness advice" can be inappropriate.
Clinician coordination
We encourage coordination with your care team, especially for supplements, probiotics, restrictive diets, or new GI symptoms.
Red flags requiring urgent medical evaluation:
If you experience any of these, seek immediate medical evaluation:
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Fever or chills
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Dehydration
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Blood in stool
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Severe abdominal pain
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Rapidly worsening symptoms
You may benefit if…
You're starting a new targeted therapy and want to support tolerance
You're "technically treated" but still symptomatic
Side effects are limiting adherence or quality of life
Antibiotics, infections, or GI instability are frequent
You suspect gut issues are amplifying inflammation or fatigue
You may need urgent medical input first if…
High fever
High fever
Signs of infection
Dehydration
Rapid decline
Frequently asked questions
Clinician Overview
Intended use
Supportive care layer for therapy-associated dysbiosis/symptoms in rare disease patients.
Communication
Shareable summary for chart + collaboration option available.
Safety guardrails
Immunocompromised caution, avoid contraindicated ingredients, align with protocols.
Outcomes tracked
Symptom burden, tolerance, nutrition/hydration stability (not "immune restoration" claims).